NOT KNOWN FACTUAL STATEMENTS ABOUT PKRRATING

The interfacial residues are extremely conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET check here measurements exhibit which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a model the place activating RNA serves being a scaffold to bind several PKR monomer

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